INDOMETHACIN-INDUCED INCREASE IN NORADRENALINE TURNOVER IN SOME RAT ORGANS
نویسندگان
چکیده
منابع مشابه
Enhancement of stress-induced increase in hypothalamic noradrenaline turnover by pretreatment with naloxone in rats.
The relationship between the increase in noradrenaline (NA) turnover and endogenous opioid peptides in the hypothalamus under stressful situations was investigated in rats using a specific antagonist of opioids, naloxone. Male Wistar rats were injected subcutaneously with saline, naloxone at 1 mg/kg or 5 mg/kg 10 min before exposure to immobilization stress for 1 hour. Levels of NA and its majo...
متن کاملIschemic preconditioning suppresses the noradrenaline turnover in the rat heart.
OBJECTIVE The mechanism by which ischemic preconditioning protects the heart is presumed to be related to the reduction of energy consumption during a subsequent myocardial infarction. Since the sympathetic nervous system enhances cardiac function and energy consumption, we investigated the relation between ischemic preconditioning and the turnover rate of noradrenaline (NA) in the rat heart. ...
متن کاملBilateral adrenalectomy does not alter stress-induced increases in noradrenaline turnover in rat brain regions.
Effects of adrenalectomy on increases in noradrenaline (NA) turnover induced by a one-hour immobilization stress were examined by measuring the levels of NA and its major metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) in specific brain regions of the rat. Bilateral adrenalectomy alone does not affect basal levels of NA and MHPG-SO4 in the brain regions examined with the ...
متن کاملDoes Propylthiouracil Increase the Gentamicin-Induced Nephrotoxicity In Rat?
Objective(s): The aim of this study was to evaluate the effect of subacute administration of propylthiouracil (PTU) on gentamicin (GM)-induced nephrotoxicity in male rats. Materials and Methods: Male Wistar rats were divided into 4 experimental groups as follow: (1) Control group: isotonic saline (1 ml/kg, IP. for 18 d), (2) GM group: 100 mg/kg, IP for 8 d, (3) PTU group: PTU...
متن کاملNoradrenaline-induced changes in rat brown adipose tissue glucagon.
Brown adipose tissue (BAT) glucagon level was higher in cold-acclimated rats (CA) than in warm controls (WC). Noradrenaline (NA) injection increased BAT glucagon levels in both WC and CA with increases in plasma glucagon levels. The magnitude of increase was significantly greater in CA for plasma glucagon, while it did not differ for BAT between groups. However, BAT glucagon was kept at a highe...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1975
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1975.tb07568.x